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Comparison of Deconvolution Algorithms
BioMass
Deconvolution
ZNova Deconvolution
60 kD protein deconvoluted spectra
The same input spectrum was processed with either BioMass or ZNova
The comparison of the deconvoluted spectra shown above demonstrate that ZNova generates much “cleaner” deconvoluted spectra than that produced by a Mann-type algorithm like that employed by the ThermoFinnigan BioMass software (4, 5).   BioMass also produces and uneven baseline from the known component removal process.  This is not observed with ZNova deconvolution, as the baseline is removed prior to processing.  Another key advantage of ZNova is that it reports statistics including standard deviation and score, which help the user determine if the transformed signals are due to real components or are due to random accumulation of noise events.
Mass(Da)
60987